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Peer reviewed papers highlighting Seralite® – FLC in diagnosis and monitoring of multiple myeloma

Seralite® – FLC, has recently featured in three respected scientific journals: Clinical Chemistry and Laboratory Medicine (CCLM); British Journal of Haematology (BJH); and BMC Nephrology.

flc testing for myeloma

In each of the publications, the authors have highlighted several benefits of using Seralite® – FLC in aiding the diagnosis and monitoring of patients with multiple myeloma and related conditions.

The authorship includes Professor Mark Drayson from the University of Birmingham; along with other experts from the University of Leeds, Newcastle University, Radboud University Medical Center, Netherlands, Harvard University, USA, and the University of Arkansas, USA.

Paper in CCLM on Analytical Method

Campbell, J. P. et al (2016). Development of a rapid and quantitative lateral flow assay for the simultaneous measurement of serum κ and λ immunoglobulin free light chains (FLC): inception of a new near-patient FLC screening tool. Clinical Chemistry and Laboratory Medicine (CCLM).

This publication discusses and evaluates the Seralite®-FLC method in detail and covers assay interference, imprecision, lot-to-lot variability, linearity and utility of a competitive-inhibition design for the elimination of antigen-excess. In addition, the publication presents and discusses preliminary clinical validation data from over 300 patients and compares the diagnostic results with other commercially available Free Light Chain Immunoassays.

This important publication validates the use of Seralite®-FLC within clinical laboratories and highlights important technical advantages of using the unique format of Seralite®-FLC such as lack of antigen excess.

Access to this publication can be obtained via the link: https://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-2016-0194/cclm-2016-0194.xml

Paper in BJH on Clinical Validation

Heaney, J. L. J. et al (2017). Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests. British Journal of Haematology

This paper features detailed clinical validation of Seralite®-FLC and highlights the importance of clinically validating different Free Light Chain methods fully to understand appropriate thresholds.

The aim of the study was to guide interpretation of Free Light Chain (FLC) testing in clinical practice and specifically discusses appropriate clinical cut-offs for Seralite®-FLC. The study examined blood and urine analysis from 5,573 newly diagnosed myeloma patients including 576 light chain only and 60 non-secretory cases.

The authors conclude that as a rapid test, Seralite®-FLC is able to overcome delays in FLC result availability to accelerate patient diagnosis and quickly inform on patient responses to therapy.

Access to this publication can be obtained via the link: http://onlinelibrary.wiley.com/doi/10.1111/bjh.14753/full

Paper in BMC Nephrology on accelerating diagnosis in cases of AKI

Heaney, J. L. J. et al (2017). Multiple myeloma can be accurately diagnosed in acute kidney injury patients using a rapid serum free light chain test. BMC Nephrology

This publication examines the use of Seralite®-FLC in the rapid diagnosis of multiple myeloma in Acute Kidney Injury patients (AKI). Renal impairment is common in multiple myeloma patients and has a negative impact on survival. In patients presenting with AKI where the underlying pathology is unknown, it is recommended that multiple myeloma should be investigated as a potential cause.

The International Myeloma Working Group recommends screening for myeloma using serum immunoelectrophoresis (IFE), serum protein electrophoresis(SPE), and serum free light chain (sFLC) assays. The timescales for routine IFE, SPE and sFLC may not be compatible with the emergency setting of a patient presenting with AKI.

The aim of the study was to assess the utility of Seralite®-FLC as a screening tool to distinguish between myeloma and non-myeloma related AKI. The publication highlights that Seralite®-FLC could reduce delays in obtaining sFLC results and accelerate diagnosis in patients with unexplained AKI.

Full access to this publication can be obtained via the link: https://bmcnephrol.biomedcentral.com/track/pdf/10.1186/s12882-017-0661-z

To learn more about Seralite® – FLC please contact us on +44 (0) 1904 406080 or at info@abingdonhealth.com, visit our product page.