In addition to developing and manufacturing rapid lateral flow tests for our clinical and contract customers, Abingdon Health manufactures a range of rapid tests for plant diseases called Pocket Diagnostic®.
The following areas are discussed to highlight how Pocket Diagnostic® was brought to market in order to help fight devastating plant diseases.
- Assay development
Pocket Diagnostic® was initially developed for use by the UK Government Plant Health Inspectors in order to provide them with a cost-effective and user-friendly, in-field rapid testing solution to use during their inspections.
Knowing that the Pocket Diagnostic® range would need to test a variety of plants and plant material the tests were enhanced to work with a variety of sample matrices such as leaf and woody plant materials.
With this in mind, the team followed a development plan that covered the following areas in order to ensure the tests worked with the intended matrices.
- Reagents testing
- Selection of membranes, samples pads, buffer selection
- Feasibility, optimisation and scale-up
Scale-up and large volume manufacture
Following assay development, the Pocket Diagnostic® range was scaled-up via a verification and validation phase in order to assess how Pocket Diagnostic’s performance would cope with the rigours of routine manufacture.
The manufacture of Pocket Diagnostic® is carried out in Abingdon’s fully automated and climatically controlled manufacturing facility, which is ISO 9001 and ISO 13485 certified and works to GMP requirements.
Since its launch, Pocket Diagnostic® has been used by a global audience across 6 continents and has provided professionals working in horticulture, forestry and food production with an in-field rapid testing solution for pathogens such as Phytophthora spp*, Potato virus Y, Erwinia amylovora (Fire Blight) and Ralstonia solanacearum (Brown Rot/Bacterial Wilt).
To learn more about Abingdon Health’s services, there are a series of videos which can be viewed by visiting https://www.abingdonhealth.com/videos/.
Alternatively, please read one of our other case studies on how we launched a rapid quantitative lateral flow test for haematology oncology. Or read about the process we will take in order to develop a multiplexed on-farm rapid test to identify a disease in cattle that affects milk production.
Why work with Abingdon Health?
- Ability to apply reagents to a lateral flow device (LFD) or convert an ELISA assay into an LFD
- Aid the transfer from initial stage R&D into a full development and manufacturing project
- Cost-effective solutions with assay and customer requirements at the forefront
- Proven track record of developing and manufacturing qualitative, semi-quantitative, quantitative, single target and multiplexed assays
- A dedicated quantitative lateral flow assay development team
- Experience of working with different sample matrices
- Access to a quality and sustainable supply of reagents and materials
- Scale-up to High volume batches utilising state of the art manufacturing facilities
- Experience of working in regulated markets
- Academia-commercial collaboration